The invention discloses a disease diagnosis system and method based on bio-electricity signal analysis. The disease diagnosis system comprises a bio-electricity information collection system, a transmission system, a data platform and a management center, the transmission system is connected with the bio-electricity information collection system and a data platform system separately, and the dataplatform system is connected with the management center. The bio-electricity information collection system is used for collecting bio-electricity signals of all acupuncture points of the human body and comprises a power supply electrode and a measuring electrode; the transmission system transmits the collected bio-electricity signals to the data platform, through the comparison of the signals andwith normal current values of all the acupuncture points of the human body in the data platform, disease characteristics of the human body are judged, and the data platform feeds a disease diagnosis report back to a user through the management center. By means of the disease diagnosis system and method based on the bio-electricity signal analysis, the user can be helped to preliminarily judge thediseases, so that the user conveniently selects hospitals and general clinics or decides about whether to go to a doctor or not with pertinence.