The invention provides a method for the preparation of 10, 10-bisubstituted-3-bromo anthrone, and belongs to the field of organic chemistry. According to the method, phthalic anhydride and bromobenzene are used as raw materials, the raw materials are sequentially subjected to a ring opening reaction, a reduction reaction, an esterification reaction, a tert alcoholization reaction, a cyclization reaction and an oxidation reaction, and 10, 10-bisubstituted-3-bromo anthrone is obtained. The raw materials in the method are cheap and easily obtained, reaction conditions are simple, and the tolerance to a bromine-containing functional group is good.