A FLUENT-based research method for obstacle-bypassing diffusion of fluorine leak is provided. Obstacles are one of important factors that affect gas explosion, and reinforcing mechanism of obstacles for fluorine leak is a hotspot in existing studies. The FLUENT-based research method for obstacle-bypassing diffusion of fluorine leak is characterized in that parameters of a physical model in a simulation space are set according to actual conditions, common geometric models are analyzed, a diffusion area is determined according to a leak source, software FLUENT is applied, parameter values are set, obstacle-bypassing diffusion of fluorine and distribution law of damage areas are simulated under the same physical models and different geometric models, effective experimental data are extracted, concentrations of fluorine gas at different points of time after fluorine leak around obstacles are further analyzed. The method of the invention is applicable to in the fields such as safety analysis and factory siting to guide people's production and living.