The invention discloses a three-degree-of-freedom large-stroke micro-positioning platform achieving driving force decoupling. The three-degree-of-freedom large-stroke micro-positioning platform comprises a micro-moving platform base body which sequentially comprises a bottom plate, a middle part and a top layer part from bottom to top; two transferring beams are arranged in the center of the middle part, wherein the first transferring beam is used for connecting the middle part and flexible hinge deformation structures of two Y-direction ends of the top layer part, and the second transferring beam is used for connecting the middle part and flexible hinge deformation structures of two X-direction ends of the top layer part; the top layer part is sequentially provided with the flexible hinge deformation structures, a moving platform and an output platform from outside to inside, and the output platform is arranged in the center of the moving platform; and the two ends of the output platform are connected with piezo-ceramic actuators through lever amplifying mechanisms correspondingly. According to the three-degree-of-freedom large-stroke micro-positioning platform achieving driving force decoupling, the flexible beams are used for connecting two decoupled parts of the moving platform, and equal distribution and decoupling of the driving force are achieved; and through driving of two voice coil motors, high-precision and large-stroke movement of the moving platform in the X-Y plane is achieved.