Medical devices, medical device systems, and methods for making and using the same are disclosed. An example medical device system may include a catheter shaft having a proximal end. A removable liner may extend through the catheter shaft. The removable liner may be designed to deliver a medical substance to a target region. The removable liner may be designed to be removed from the catheter shaft if the removable liner becomes plugged. The system may also include a replacement liner. The replacement liner may be designed to be inserted within the catheter shaft after the removal of the removable liner. A support member may be disposed along the replacement liner.