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发明公开
CN107400073A 一种4-异硫氰基-2-（三氟甲基）苯甲腈的合成方法 无效 - 驳回

一种4-异硫氰基-2-（三氟甲基）苯甲腈的合成方法
摘要：
本发明公开了一种4-异硫氰基-2-(三氟甲基)苯甲腈的合成方法，该方法分为如下两步：步骤一，以3-三氟甲基-4-氰基苯胺(I)为起始原料，与硫代氯甲酸苯酯在二氯甲烷等有机溶剂中反应得到中间体(II)；步骤二，中间体(II)在甲苯中回流反应脱去一分子苯酚得到式(III)产物4-异硫氰基-2-(三氟甲基)苯甲腈，反应式如下：本发明方法成本低、安全环保，操作简易，适用于工业化生产。
摘要（英）：

The invention discloses a synthetic method of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile. The synthetic method comprises following two steps: step 1, 3-trifluoromethyl-4-cyanoaniline (I) is taken as an initial raw material, and is reacted with phenyl chlorothionocarbonate in an organic solvent such as dichloromethane so as to obtain an intermediate (II); and step 2, the intermediate (II) is subjected to backflow reaction in toluene so as to remove one molecular phenol so as to obtain the finished product 4-isothiocyanato-2-(trifluoromethyl) benzonitrile represented by formula (III). The reaction equation is discloses in the invention. The synthetic method is low in cost, is safe, is friendly to the environment, is simple in operation, and is suitable for industrialized production.

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