A synthetic method of a chiral compound (I) comprises the steps that palladium chloride of 33mol% as a catalyst, 3.4382 g of N-cyanoacetylpyrrolidine, 60 mL chlorobenzene and 4.8075 g of D-plenylglycinol are mixed, the mixture is subjected to reflux at a high temperature for 60 h, then the reaction is stopped, and pressure is reduced so as to remove a solvent; the residues are dissolved with water and extracted with CHCl3 (20 mL x2), the organic phase is dried by using anhydrous sodium sulfate, a solvent is removed through rotation, and then the residues pass through a silica gel chromatographic column for separation and purification; elution is conducted by using a mixture liquid of petroleum ether and dichloromethane in a volume ratio of 1:9, a first component point is collected, and the target product, namely (R)-(+)-alpha-phenyl-2-chlorophenethylamine, is obtained after an eluent is removed, wherein the chemical formula is shown in the description. According to the application of the chiral compound, the chiral compound as a catalyst is used in a Henry reaction of ethyl pyruvate and a reaction of benzaldehyde and benzoyl amide, and the conversion ratio of the Henry reaction and the conversion ratio of the reaction of benzaldehyde and benzoyl amide reach 41% and 94% respectively.