The invention discloses a preparation method of a pumpkin-seed premix-powder base material for baked product, and belongs to the technical field of food processing. The preparation method of the pumpkin-seed premix-powder base material for the baked product comprises the following nine major steps of performing pretreatment on pumpkin seeds, carrying out roasting, carrying out oil extraction, removing impurities from skimmed pumpkin seed meal, carrying out ultra-fine crushing, carrying out extrusion by performing dual twin-screw extruding, carrying out drying and crushing, adding auxiliary materials, as well as carrying out packaging. By performing supercritical carbon dioxide extraction on the pumpkin seed meal according to the preparation method, heterozygous peculiar odor, residual grease and fat-soluble pigments contained in the pumpkin seed meal can be effectively removed; and thus, sensory quality and shelf lives of the baked products prepared from the pumpkin-seed premix-powder base material can be significantly improved. Moreover, ultra-fine crushing and extrusion by performing dual twin-screw extruding are performed on the pumpkin seed meal so that soluble dietary fiber content and protein solubility are improved so as to further increase absorption and digestion rates, as well as processing performance, of the pumpkin-seed premix-powder base material for the baked product; and thus, the baked products produced by using the pumpkin-seed premix-powder base material for the baked product are good in sensory quality, free of taste of gravel, free of speckle, as well as fine and smooth in taste. The pumpkin-seed premix powder for the baked product enriches types of baked products on the market; moreover, the skimmed pumpkin seeds are used for food production so that added values of the pumpkin seeds are increased.