The invention relates to a beta-trifluoromethyl enamine derivative. The structural general formula of the beta-trifluoromethyl enamine derivative is as follows: formula (shown in the description), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 are independently selected from hydrogen, alkyl, alkoxy, halogen or trifluoromethyl. The invention further provides a preparation method of the beta-trifluoromethyl enamine derivative. The preparation method comprises the step of reacting by virtue of an N-(2-phenyl-1-vinyl)benzamide derivative and a tongi reagent at 80-100 DEG C in an organic solvent in the presence of alkali, a ligand and a copper salt catalyst, so as to obtain the beta-trifluoromethyl enamine derivative. According to the preparation method, several beta-trifluoromethyl enamine derivatives can be obtained in a high yield manner; reaction conditions are mild, and the operation and post-treatment processes are simple, and the preparation method is applicable to large-scale production.