The invention relates to a processing method of cassava whole powder puffed rice cakes. The processing method is characterized in that in the extrusion and puffing process, cassava leaf coarse fibers are reduced, content of soluble dietary fibers is increased, the digestion rate of the rice cakes is increased, sucrose is suitably added when the rice cakes are extruded and puffed, so that sweetness of the rice cakes can be increased, viscosity of melt materials in an extrusion cavity is increased, tissue structure is uniform and fine, a small quantity of grease is added, flavors of the rice cakes are improved, the grease can also serve as lubricating agents to adjust input of the mechanical properties, friction between the materials and friction among the materials, the cavity and a screw body are relieved, and the processing capacity of an extruding machine is improved.