The invention provides a composition and application thereof, and particularly provides a composition for decreasing blood sugar. The composition contains a first active component with berberine being an effective component and a second active component with timosaponin being the effective component; moreover, the effective component ratio V1 (mg: mg) of the first active component to the second active component is (1.5-6): 1. The composition can fast and effectively decrease the blood sugar and the drug feeding dose of the composition can be remarkably lowered at the same time, and adverse reactions of drugs can be reduced and a safe window is expanded.