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发明公开
CN107119115A 一种检测TP53基因突变以诊断膀胱癌的方法及试剂盒 审中-实审

一种检测TP53基因突变以诊断膀胱癌的方法及试剂盒
摘要：
本发明涉及一种通过分子生物学检测手段诊断膀胱癌的技术，具体提供一种通过检测TP53基因突变以诊断膀胱癌的方法及试剂盒，其包括对TP53基因的外显子5、外显子7和外显子8进行检测，以确定上述外显子中是否存在突变。经过双盲筛试验，本发明所述试剂盒对膀胱癌的阳性检出率超过85％、阳性准确率为超过98％、阴性准确率超过97％，具有良好的临床应用价值。
摘要（英）：

The invention relates to a technology for diagnosing the bladder cancer through a molecular biology detection measure, in particular to a method and a kit for detecting the mutation of a gene TP53 to diagnose the bladder cancer. The method comprises the following step: detecting an exon 5, an exon 7 and an exon 8 of the gene TP53, so as to determine whether the exons are mutated or not. Through a double-blind screening test, the bladder cancer positive detection rate of the kit exceeds 85 percent, the positive accuracy exceeds 98 percent, and the negative accuracy exceeds 97 percent; the method has a good clinical application value.

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