The invention discloses a medicinal composition with pitavastatin calcium and a preparation method of the medicinal composition. The medicinal composition is prepared by using a direct powder compression method. The medicinal composition comprises the following raw and auxiliary materials: 0.4-5.3% of pitavastatin calcium, 60-87.6% of a filling agent, 8.7-24.4% of a disintegrating agent, 0.4-10% of an adhesive, 0.4-7.7% of a stabilizer and 0.4-2.7% of a lubricant, wherein the particle size of the stabilizer meets a sieve of 80 meshes; the particle size of the lubricant meets a sieve of 60 meshes; the particle size of the pitavastatin calcium is less than 160mu m. Due to control on the formula of the raw and auxiliary materials, the particle sizes of the materials, and the like, the medicinal composition with the pitavastatin calcium is prepared by using a simple mixing process, the medicinal composition is good in stability, low in content of related substances, and good in content uniformity, and the content of total impurities is not greater than 0.20% within 6 months of acceleration. The preparation process disclosed by the invention is simple to operate, the production time is shortened, and the production efficiency is greatly improved.