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发明公开
CN107050053A 一种由川芎醇提物制备的含药血清及其制备方法和应用 无效 - 驳回

  • 专利标题： 一种由川芎醇提物制备的含药血清及其制备方法和应用
  • 专利标题（英）： Drug serum prepared from ligusticum wallichii alcohol extract as well as preparation method and application thereof
  • 申请号： CN201710055451.9
    申请日： 2017-01-25
  • 公开(公告)号： CN107050053A
    公开(公告)日： 2017-08-18
  • 发明人: 孔晶 , 周亚楠 , 刘永红
  • 申请人： 淮阴工学院
  • 申请人地址： 江苏省淮安市经济技术开发区枚乘东路1号
  • 专利权人： 淮阴工学院
  • 当前专利权人： 淮阴工学院
  • 当前专利权人地址： 江苏省淮安市经济技术开发区枚乘东路1号
  • 代理机构： 南京苏高专利商标事务所
  • 代理商 柏尚春
  • 主分类号： A61K35/16
  • IPC分类号： A61K35/16 ;  A61K36/236 ;  A61P35/00 ;  A61P35/04
一种由川芎醇提物制备的含药血清及其制备方法和应用
摘要：
本发明公开一种由川芎醇提物制备的含药血清及其制备方法和应用，该川芎醇提物制备的含药血清为将川芎醇提物对大鼠进行灌胃后，采血得到。本发明制备的含药血清可有效抑制MG‑63骨肉瘤细胞的增殖、促进其凋亡、抑制其转移，其效果明显优于川芎提取物以及现有治疗骨肉瘤的药物；具有抑制骨肉瘤的良好效果，该川芎醇提物制备的含药血清制备的药物在治疗骨肉瘤时也具有显著的效果；同时本发明的制备方法安全可控，并且便于操作、保管、贮存和运输。
摘要（英）：

The invention discloses a drug serum prepared from a ligusticum wallichii alcohol extract as well as a preparation method and application thereof. The drug serum prepared from the ligusticum wallichii alcohol extract is prepared by carrying out gavage for mice with the alcohol extract of ligusticum wallichii and then sampling blood of the mice. The drug serum disclosed by the invention is capable of effectively inhibiting proliferation, promoting apoptosis and inhibiting metastases of MG-63 osteosarcoma cells, has an effect which is remarkably superior to a ligusticum wallichii extract and conventional medicines for treating osteosarcoma and has a good effect of inhibiting osteosarcoma, a medicine prepared from the ligusticum wallichii alcohol extract also has a remarkable effect in treating osteosarcoma, and meanwhile the preparation method disclosed by the invention is safe and controllable, convenient to operate, preserve, store and transport.

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