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发明公开
CN107043770A 一组结核病相关的外周血淋巴细胞miRNA及其应用 有权

一组结核病相关的外周血淋巴细胞miRNA及其应用
摘要：
本发明属于动物生化免疫技术领域，具体涉及一组结核病相关的外周血淋巴细胞miRNA及其应用。本发明的外周血淋巴细胞miRNA可以作为早期检测外周血淋巴细胞miRNA标志蛋白。所述外周血miRNA标志蛋白为联合使用，相关外周血miRNA序列分别如下所述：1)标志蛋白has-miR-374b-5p miRNA序列ACUAUAGAACUUUCCCCCUC A；2)标志蛋白has-miR-625-3p：GACUAUAGAACUUUCCCCCUCA和3)标志蛋白has-miR-362-5p：AAUCCUUGGAACCUAGGUGUGAGU。还公开了扩增上述标志蛋白的引物序列。本发明的标志蛋白可以作为早期检测人结核病的标志物。
摘要（英）：

The invention belongs to the technical field of animal biochemical immunization, and particularly relates to a group of peripheral blood lymphocyte miRNAs related to tuberculosis and applications thereof. The peripheral blood lymphocyte miRNAs can be adopted as peripheral blood lymphocyte miRNA marker proteins for early detection. The peripheral blood lymphocyte miRNA marker proteins are used in a combined manner. Related peripheral blood lymphocyte miRNA sequences include 1) an miRNA sequence that is ACUAUAGAACUUUCCCCCUC A of a marker protein has-miR-374b-5p, 2) an miRNA sequence that is GACUAUAGAACUUUCCCCCUCA of a marker protein has-miR-625-3p, and 3) an miRNA sequence that is AAUCCUUGGAACCUAGGUGUGAGU of a marker protein has-miR-362-5p. Primer sequences for amplifying the marker proteins are also disclosed. The marker proteins can be adopted as markers for early detection of human tuberculosis.

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