The invention provides a toughening and plasticizer migration-resisting polyvinyl chloride material as well as a preparation method and application thereof and relates to the technical field of macromolecular materials. The preparation method of the toughening and plasticizer migration-resisting polyvinyl chloride material comprises the following steps: preparing laminar di-hydroxyl metal oxide through a high-temperature hydrothermal method; carrying out surface modification on the laminar di-hydroxyl metal oxide by utilizing dopamine, dopamine hydrochloride or a dopamine derivative, so as to obtain polydopamine modified laminar di-hydroxyl metal oxide; finally, mixing polyvinyl chloride, a plasticizer, a stabilizer and the polydopamine modified laminar di-hydroxyl metal oxide to obtain modified polyvinyl chloride. The prepared material has the advantages of relatively remarkable toughening and plasticizer migration-resisting properties and the like, and the compatibility of inorganic nanoparticles and the polyvinyl chloride is improved; furthermore, polydopamine can be used for preventing a polymer matrix from being degraded in an UV (Ultraviolet) illumination process, the performance stability of the polyvinyl chloride material is improved and the service life of the polyvinyl chloride material is prolonged.