The invention provides preparation and application of an amide compound. The preparation method comprises the steps: adding a first compound and a second compound into a vessel, and carrying out a reaction in the presence of K2CO3 and THF, so as to obtain a third compound, wherein the first compound is represented by a formula shown in the description, the second compound is represented by a formula shown in the description, and the third compound is represented by a formula shown in the description; subjecting the third compound to a reaction in the presence of zinc powder, dichloromethane and acetic acid, so as to obtain a fourth compound, wherein the fourth compound is represented by a formula shown in the description; subjecting the fourth compound to a reaction with a fifth compound in the presence of triethylamine and THF, so as to obtain a sixth compound, wherein the fifth compound is represented by a formula shown in the description, and the sixth compound is represented by a formula shown in the description; subjecting the sixth compound to a reaction with a seventh compound in the presence of CuI, Pd(PPh3)Cl2, triethylamine and DMF, so as to obtain an eighth compound, wherein the seventh compound is represented by a formula shown in the description, and the eighth compound is represented by a formula shown in the description; and subjecting the eighth compound to a reaction in the presence of acetic acid, anisole and dichloromethane, so as to obtain a ninth compound, i.e., a first target compound represented by a formula shown in the description. The compound prepared by the method provided by the invention plays roles in inhibiting tyrosine kinase and treating leukemia.