The invention discloses a vehicle-mounted wireless radio frequency communication system, which comprises a vehicle-mounted sound system, a control module, a power detection module, a power module, a switch button, a line selection module, a radio frequency transceiver module and a radio frequency earphone. The system is provided with two paths of audio lines, that is, a loud speaker and the audio frequency earphone, and line selection is realized through the line selection module, so that when a user answers the call with the radio frequency earphone, call voice is transferred to the earphone, and the loud speaker in a vehicle no longer speaks; and when the call is over, an audio can be resumed to output from the original loud speaker through the switch button, thereby solving the problem that since an existing bluetooth earphone cannot interact with the sound system, driving safety is threatened especially when a driver both listens to the audio and answers the phone with the earphone during driving.