The invention discloses an engine system and an automobile applying the same. The engine system comprises an air cylinder body, an air cylinder cover, an exhaust mechanism, multiple air valve actuators, a first turbocharger and a second turbocharger. Combustion chambers are formed by the air cylinder body and the air cylinder cover, wherein each combustion chamber is provided with an air inlet set and an exhaust opening set. Each air inlet set comprises air inlets provided with air inlet valves. Each exhaust opening set comprises a first exhaust opening provided with a first exhaust valve and a second exhaust opening provided with a second exhaust valve. Each air valve actuator is arranged to independently control the corresponding air inlet valve or the corresponding first exhaust valve or the corresponding second exhaust valve. Each first exhaust opening is connected with an air inlet of a first turbo machine of the first turbocharger, and each second exhaust opening is connected with an air inlet of a second turbo machine of the second turbocharger. By means of the engine system and the automobile applying the same, the on and off time of each exhaust valve and each air inlet valve can be controlled independently and precisely so that the engine system and the automobile applying the same can be adapted to different working conditions; and the proportion of exhaust gas passing through the first turbocharger and the second turbocharger can be controlled.