The invention discloses a water solubility platinum complex containing deoxyglucose and a preparation method and application. The water solubility platinum complex containing the deoxyglucose is shown as the formula (1) (please see the formula in the specifications). The water solubility platinum complex containing the deoxyglucose has an excellent tumor selective drug accumulation effect, and drug resistance formed by a repulsive effect of a tumor to drugs is overcome through targeting performance transmission to tumor cells. Compared with clinical drugs, the water solubility platinum complex containing the deoxyglucose has higher water solubility and is capable of achieving clinical preparation easily. Compared with the clinical drug, namely, oxaliplatin, the water solubility platinum complex containing the deoxyglucose has superiority in the aspect of cytotoxicity. In conclusion, according to the water solubility platinum complex containing the deoxyglucose, not only is the problem of poor preparation stability and the shortcoming of inconvenient clinical using in existing platinum drugs because of lacking in water solubility solved, but also targeting performance of the drugs to tumor cells can be improved, and the deficiency of the existing clinical drugs in the aspects of the tumor therapy effect, the drug resistance and toxic and side effects is solved.