The invention discloses an unmanned aerial vehicle interference method, an unmanned aerial vehicle interference system and an unmanned aerial vehicle interference device based on infrared thermal imaging. The method comprises the following steps of setting a predetermined airspace receiving range, and dividing the airspace receiving range into a plurality of areas; setting a predetermined image library in which an infrared thermal imaging feature parameter of the unmanned aerial vehicle is pre-stored; receiving thermal infrared radiation signals within the receiving range at predetermined intervals; acquiring infrared image feature data by processing the thermal infrared radiation signals; comparing the feature data with the feature parameter stored in the predetermine image library, and if a comparison result indicates that the feature data is accordant with the feature parameter, computing an area position to which the unmanned aerial vehicle currently belongs in the thermal image; and sending an interference signal to the area position, wherein the interference signal is used for interfering a communication link between the unmanned aerial vehicle and an unmanned aerial vehicle controller. According to the method, the system and the device provided by the invention, the invasive unmanned aerial vehicle can be interfered without accurately positioning and real-time tracking the unmanned aerial vehicle, cost is low, operation is simple, and lots of computation resources are not needed.