The invention discloses an air compression system group control method. The air compression system group control method comprises the following steps: firstly, monitoring operating data of each air compressor set; secondly, analyzing the aspects, such as the rated air production amount F.max of each air compressor set, the minimum compressed air flow supply amount Fv.min when a variable frequency air compressor set operates at a minimum frequency, operating time, unloading time and faults, by analyzing the monitored data of each air compressor set; thirdly, detecting the air supply pressure and the air supply flow of an air compression system and the air supply flow of each air compressor set and optimizing an air compressor set group control strategy. According to the air compression system group control method, the operating system of the air compression system is improved; normal operation of each air compressor set is ensured; the air compressor set shutdown and air compressor set unloading time are reduced. The purpose of operating the group control of air compressor sets is realized, and the purposes of optimizing control, improving the operating efficiency of the air compression system, improving the energy use efficiency and guaranteeing the production are achieved.