The present invention discloses a halogenation reaction method, which comprises: mixing at least an organic compound to be halogenated, a halogenating agent and a solvent capable of being optionally added or being not added and/or a diluent in a super gravity reactor to form a liquid-state reaction system, and carrying out a halogenation reaction to produce the halogenated product, preferably the super gravity level of the super gravity reaction is 5-800 g during the halogenation reaction. According to the present invention, the super gravity reactor such as the super gravity rotating bed reactor is used to perform the halogenation reaction, such that the rapid and microscopic mixing between the organic compound to be halogenated and the halogenating agent can be achieved, various kinds of side reactions caused by the too high local concentration can be effectively avoided, and the yield and the quality of the product can be significantly improved.