The invention discloses a large-scale breeding method of large-size fingerlings of Pelteobagrus fulvidraco Huangyou No.1. The large-scale breeding method comprises the following steps: 1, selecting a pond; 2, disinfecting the pond; 3, putting eating-beginning fingerlings into the pond; 4, feeding bait; 5, performing water quality management. With the large-scale breeding method, a key for directly taming the eating-beginning fingerlings of the Pelteobagrus fulvidraco to eat compound feed for producing the large-size fingerlings is broken through at home for the first time; by a technology that a fingerling throwing area is enclosed by a net for taming eating in a centralized way, the eating-beginning fingerlings of the Pelteobagrus fulvidraco are directly tamed to eat the compound feed, so that an operating procedure is simple and convenient and management is easy; in aspects of fingerling breeding and bait feeding and the like, the large-size fingerlings are innovatively tamed by using the artificial compound feed to achieve successful eating conversion; the survival rate of the fingerlings is above 85%; the water quality of aquaculture water can keep good; most effective practical measures and means are created for sufficiently developing the hybrid Pelteobagrus fulvidraco Huangyou No.1 as a famous and extrasuperior breeding variety; therefore, the large-scale breeding method has significant social and economic benefits.