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发明公开
CN106243060A 2-(R2-硫代)-10-[3-(4-R1-哌嗪-1-基)丙基]-10H-吩噻嗪用于治疗β-淀粉样病或α-共核蛋白病以及诊断或前诊断它们的方法 无效 - 撤回

2-(R2-硫代)-10-[3-(4-R1-哌嗪-1-基)丙基]-10H-吩噻嗪用于治疗β-淀粉样病或α-共核蛋白病以及诊断或前诊断它们的方法
摘要：
白转运的物质。本发明涉及通式I的2-(R2-硫代)-10-[3-(4-R1-哌嗪-1-基)丙基]-10H-吩噻嗪，用于治疗伴有脑蛋白沉积和脑ABCC1-转运蛋白活性降低的β-淀粉样病或α-共核蛋白病。本发明还涉及诊断或前诊断伴有脑蛋白沉积和脑ABCC1-转运蛋白活性降低的β-淀粉样病或α-共核蛋白病的方法，或者确定受试者罹患此种疾病的风险的方法，所述受试者已经累积了由脑ABCC1-转运蛋
摘要（英）：

The invention relates to 2-(R2-thio)-10-[3-(4-R1-piperazine-1-yl)propyl]-10H-phenothiazine represented by a formula (I). The compound is used to treat beta-amyloidopathia or alpha-synucleinopathy with symptoms of brain protein deposition and reduced activity of brain ABCC1-transport protein. The invention also relates to a method for diagnosing or pre-diagnosing beta-amyloidopathia or alpha-synucleinopathy with symptoms of brain protein deposition and reduced activity of brain ABCC1-transport protein or a method for determining the risk that a tested person gets the disease; and the tested person already has accumulated substances transported by the brain ABCC1-transport protein.

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