知搜-全球专利检索

  1. 登录
  2. 注册
发明公开
CN105969746A 可拆分外消旋胺制备手性胺的转氨酶及其编码基因与应用 审中-实审

可拆分外消旋胺制备手性胺的转氨酶及其编码基因与应用
摘要：
本发明涉及生物技术领域，更具体地涉及一种可拆分外消旋胺制备手性胺的转氨酶及其编码基因与应用。转氨酶是如SEQ ID NO.1所示的氨基酸序列，转氨酶的基因是如SEQ ID NO.2所示的碱基序列。采用本发明所述转氨酶作为催化剂来拆分外消旋胺，与化学法相比，有着高的选择性和转化率，且反应条件温和，对环境无污染，对于医药及化工领域手性胺的高效、绿色合成具有重大意义。
摘要（英）：

The invention relates to the field of biotechnology, more particularly to a transaminase for preparing chiral amine by racemic amine as well as a coding gene and application of the transaminase. The transaminase has an amino acid sequence as shown in SEQ ID NO.1, and the gene of the transaminase is a base sequence as shown in SEQ ID NO.2. The transaminase serves as a catalyst to resolve racemic amine. In comparison with a chemical method, high selectivity and conversion ratio are achieved, the reaction conditions are mild, environmental pollution is prevented, and significance on efficient and green synthesis of chiral amine in the medical and chemical industry is realized.

0/0