An LS-DYNA based method for optimally designing a layout of a storage tank area of a chemical industry park. The present invention relates to an LS-DYNA based method for optimally designing a layout of a storage tank area of a chemical industry park. An objective of the present invention is to solve the problems that the existing design method is poor and even unsuccessful in design, and basic materials may have expired, and actual on-site conditions have changes and the like. The method is specifically implemented according to the following steps: 1. defining a constraint condition of selecting a storage tank area of a chemical industry park as a model parameter of numerical simulation, and then generating a keyword k file; 2. inputting the keyword k file into LS-DYNA software to perform resolution so as to obtain a d3plot result file; 3. obtaining a breakage effect value of a whole explosion course; and 4. obtaining a layout manner with a smallest breakage effect value of the whole explosion course of the storage tank area, so as to obtain an optimized design scheme. The method provided by the present invention is applied to the field of layout optimization of the storage tank area of the chemical industry park.