The invention provides a preparation method of a high-performance oxidized graphene tubular nanofiltration membrane and an application thereof, and belongs to the field of membrane separation technology. The method comprises the following steps: ultrasonic dispersion is carried out for oxidized graphene sheets in deionized water, and a uniformly dispersed aqueous solution of oxidized graphene is obtained; an anion activator is added into the aqueous solution with continuously stirring, and membrane casting liquid is obtained; a porous ceramic membrane after pretreatment with dopamine is immersed in the membrane casting liquid, the membrane is taken out after a certain period time and placed in an oven for drying, and the oxidized graphene tubular nanofiltration membrane with high dye removing performance is obtained. The nanofiltration membrane prepared by the method has the characteristics of high retention rate, high flux, etc., the preparation process is simple and convenient, and the nanofiltration membrane is widely applied to the field of water treatment.