The invention discloses a method for making giant salamander health maintaining wine. The method comprises the following steps that 1, for each 100 kg of 65-degree baijiu, 1,400 g to 1,600 g of giant salamander raw materials, 300 g to 600 g of ginseng, 500 g to 700 g of cornua cervi pantotrichum, 700 g to 900 g of radix polygonati officinalis, 900 g to 1,100 g of longan, 400 g to 600 g of sealwort, 900 g to 1,100 g of mulberries, 500 g to 700 g of rhodiola rosea, 1,400 g to 1,600 g of honey and 1,900 g to 2,100 g of rock candy are prepared, wherein the giant salamander raw materials are composed of heads, tails and bones of giant salamander; 2, drying is carried out; 3, bagging and thermal steaming are carried out; 4, the giant salamander raw materials are subjected to biochemical treatment; 5, the raw materials above are steeped in baijiu for extraction for more than 10 days, and then the extracting solution is blended into a 40-degree wine; 6, the mixed wine is filtered, sterilized and bottled, and the finished product is made.