The invention discloses a method for changing cell fate. The method includes inducing cells to carry out mitochondrial flash. The cells are somatic cells. The method has the advantages that as discovered by the inventor, the cells can be induced to carry out mitochondrial flash, and reprogramming of the cells can be obviously promoted if the cells are induced to carry out mitochondrial flash by the aid of the method implemented by medicines (such as paraquat and mastoparan) or genes (such as cell over-expression cyclophilin D).