The invention provides an end-to-end cluster key distribution method and core network equipment (eCN). The core network equipment (eCN) receives a first push-to-talk speaker request message from speaker UE, and sends a first key request message to a key distribution center (KDC); the key distribution center (KDC) returns a first key response message to the eCN when the speaker UE has an encrypted call permission of a target group; and the eCN establishes speaker load, sends a first push-to-talk speaker accept message to the speaker UE and establishes group downlink load and sends a key indication message to called UE periodically, wherein the first key response message, the first push-to-talk speaker accept message and the key indication message comprise group keys or key data used for calculating the group keys. The end-to-end cluster key distribution method and core network equipment can realize end-to-end cluster key distribution of a time-division long-term evolution (TD-LTE) cluster communication system.