The invention discloses an information network attack-oriented vulnerability node evaluation method for a power grid. The method comprises the steps as follows: a topology frame of a physical power grid information system is generated; a frame model comprises all target states of a physical power grid system; information attack action position and way are constructed; and evaluation of the system vulnerability is carried out. According to the information network attack-oriented vulnerability node evaluation method for the power grid, the vulnerability in the physical power grid information system is analyzed by combining a malicious attack of an information network from a global viewpoint; the method disclosed by the invention is relatively objective and accurate; security defense opinions and suggestions are provided for grid companies and related departments; and information security and stable operation of a power transmission network and a power distribution network are ensured.