The invention discloses a full-automatic sample pretreatment instrument. The full-automatic sample pretreatment instrument comprises a machine case and a control cabinet connected with the machine case. A controller is installed in the control cabinet. A disc is installed in the machine case, a plurality of tube sleeves used for carrying centrifugal tubes are evenly distributed on the disc and rotationally connected to the disc, a driving device used for driving the disc to rotate is installed in the machine case, and a liquid adding device for adding reagents into the centrifugal tubes is installed at the portion, located on one side of the disc, in the machine case. A heating device which can move up and down and is used for heating the centrifugal tubes is arranged at the portion, located at the lower portion of the disc, in the machine case. A stirring device capable of extending into the centrifugal tubes to carry out shearing stirring is arranged at the portion, located at the upper portion of the disc, in the machine case. The full-automatic sample pretreatment instrument has the advantage of being high in automation degree; by means of the full-automatic sample pretreatment instrument, automatic pretreatment of various samples can be achieved, the labor intensity of an operator is reduced, and detection efficiency is greatly improved.