The invention relates to a packaging method of a full-automatic box-packing packaging system. The packaging method includes the steps that (1) wine bottles are fed; (2) a separating screw is used for separating the wine bottles by a distance; (3) a star wheel is used for conveying the wine bottles in a spaced mode; (4) a distributing mechanism is used for pushing the wine bottles; (5) a lifting bottle packaging mechanism is used for grabbing the wine bottles from the distributing and pushing mechanism and lifting the wine bottles upwards; (6) paper boxes are fed; (7) a box sucking mechanism sucks the paper boxes and unfolds the paper boxes; (8) a box clamping mechanism conveys the paper boxes; (9) a bottom sealing mechanism is used for sealing the bottoms of the paper boxes; (10) a guide wheel mechanism is used for outwards turning and folding box covers of the paper boxes; (11) the lifting bottle packaging mechanism places the wine bottles into the paper boxes which are subjected to edge folding through the guide wheel mechanism; (12) a cover pressing mechanism is used for pressing bottle clamping folded edges of the paper boxes and positioning the paper boxes; (13) a cover sealing mechanism is used for sealing the paper boxes; and (14) packaging is completed, and the paper boxes are output. All packaging processes are completed fully automatically, compared with existing manual and half-manual box packing, technical promotion is achieved by a large margin, the rapid box packing requirement is met, and a stable and reliable state is still kept in rapid operation.