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发明公开
CN105343107A 雷公藤红素在制备防治视网膜退行性改变相关疾病药物中的应用 无效 - 撤回

雷公藤红素在制备防治视网膜退行性改变相关疾病药物中的应用
摘要：
本发明涉及雷公藤红素在制备防治视网膜退行性改变相关疾病药物中的应用。本发明采用视网膜光损伤的小鼠模型，模拟多种视网膜退行性病变发生过程中的共同病理环节，即光感受器细胞死亡，对雷公藤红素抗光感受器细胞死亡、防治视网膜退行性病变发生的作用进行了研究，结果表明雷公藤红素对光损伤诱导的光感受器细胞大量死亡、视网膜结构及功能的损伤具有抑制作用，能治疗并改善视网膜退行性病变，且效果十分显著，因此可用于制备治疗包括年龄相关性黄斑变性、视网膜色素变性、Stargardt病、视锥-视杆细胞营养不良、糖尿病视网膜病变等在内的多种视网膜退行性病变药物，或制备用于相关科学研究的试剂。
摘要（英）：

The invention relates to application of tripterine to preparation of medicine treating degenerative retinopathy related diseases. A mouse model suffering from retinal photodamage is adopted to simulate a common pathological link in various degenerative retinopathy generation processes, that is, death of photoreceptor cells; the photoreceptor cell death preventing function and the degenerative retinopathy preventing function of tripterine are researched, wherein the results show that tripterine can be used for inhibiting mass dead of the photoreceptor cells and structural damage and functional injury of a retina caused by photodamage, and is very obvious in degenerative retinopathy treating effect. Therefore, tripterine can be used for preparing medicine treating various types of degenerative retinopathy including age related macular degeneration, retinitis pigmentosa, Stargardt disease, cone-rod dystrophy, diabetic retinopathy and the like, or preparation of reagents used in related scientific researches.

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