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CN105294422A 生产3,5-二甲基十二烷酸的方法以及4-羧基-3,5-二甲基-3,5-十二碳二烯酸 有权

生产3,5-二甲基十二烷酸的方法以及4-羧基-3,5-二甲基-3,5-十二碳二烯酸
Abstract:
提供了简单和有效地生产3,5-二甲基十二烷酸的短方法以及4-羧基-3,5-二甲基-3,5-十二碳二烯酸，3,5-二甲基十二烷酸为加州锯天牛的信息素的活性成分，4-羧基-3,5-二甲基-3,5-十二碳二烯酸是用于生产3,5-二甲基十二烷酸的中间体。更具体地，提供了生产3,5-二甲基十二烷酸的方法，其包括如下步骤：将3-甲基-2-戊烯-1,5-二酸二酯(1)与2-壬酮(2)进行缩合反应和随后的水解反应以成为4-羧基-3,5-二甲基-3,5-十二碳二烯酸(3)；将所述4-羧基-3,5-二甲基-3,5-十二碳二烯酸(3)脱羧或者脱羧并水解为3,5-二甲基-2,4-十二碳二烯酸(4)；以及将所述3,5-二甲基-2,4-十二碳二烯酸(4)氢化为3,5-二甲基十二烷酸(5)，如以下方案所示：
Abstract(English):

Provided are a short process for simply and efficiently producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus, and 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid which is an intermediate useful for producing 3,5-dimethyldodecanoic acid. More specifically, provided is a method for producing 3,5-dimethyldodecanoic acid, comprising the steps of subjecting 3-methyl-2-pentene-1,5-diacid diester (1) and 2-nonanone (2) to a condensation reaction and subsequent hydrolysis into 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid (3); decarboxylating or decarboxylating and hydrolyzing the 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid (3) into 3,5-dimethyl-2,4-dodecadienoic acid (4); and hydrogenating the 3,5-dimethyl-2,4-dodecadienoic acid (4) into 3,5-dimethyldodecanoic acid (5), as shown in the following scheme in the description.

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