The invention relates to a personalized maxillofacial surgery guide plate and a manufacturing method thereof. The manufacturing method comprises the following steps: performing reverse modeling by CT scanning, then performing positive auxiliary modeling by Unigraphics NX, precisely repairing a surgery guide plate model, performing a simulation analysis on the surgery guide plate model by a finite element analysis method, performing an optimal design on the model according to an analysis result to enable the model to meet the property of an surgery guide plate material; performing three-dimensional slicing layering processing on the surgery guide plate model meeting the property of the surgery guide plate material, reasonably controlling the parameters of the model by adopting selective laser melting equipment, and forming to obtain the personalized maxillofacial surgery guide plate. According to the manufacturing method, the accuracy of direction and the size of stress on the maxillofacial surgery guide plate and the forming precision are effectively guaranteed; compared with the prior art, the manufactured personalized maxillofacial surgery guide plate can accord with the jawbone feature of a patient more precisely, so that secondary injury to the appearance or the body of the patient is avoided.