The invention relates to a compound with a formula (III) defined in the specification, a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorphic substance, an ester, an isomer or a prodrug of the compound, a drug composition containing the compound with the formula (III) and an application of the drug composition as an irreversible inhibitor of selective Bruton tyrosine kinase to prevention or treatment of inflammation, autoimmune diseases (such as rheumatoid arthritis) related with abnormal B cell proliferation, and cancers.