The invention provides a methoxy elgenol derivative. The methoxy elgenol derivative is characterized in that the general formula of the methoxy elgenol derivative is shown (please see the formula in the instruction), wherein R is methyl or ethyl or propyl or butyl or isobutyl. The invention further provides a preparation method of the methoxy elgenol derivative. Dihydromyrcenol is taken as a raw material, and after etherification and epoxidation, the obtained product is subjected to hydrogenation reduction to obtain the methoxy elgenol similar derivative. According to the methoxy elgenol derivative and the preparation method thereof, the raw material is low in price and easy to obtain, simple and safe effects are achieved, the environmentally friendly effect is achieved, the range of application is wide, post processing is simple, the yield is high, the method for synthesizing the methoxy elgenol derivative is fast and efficient, and the methoxy elgenol derivative has strong and favorable sandalwood odor and cool and refreshing flowery fragrance.