The invention particularly discloses a high-efficiency and low-resistance impurity particle filter system for venous transfusion, solving the problem that an existing venous transfusion filter system is unreasonable in structure design and poor in filter effect, thus causing potential safety hazards. The high-efficiency and low-resistance impurity particle filter system for venous transfusion comprises a murphy's dropper, wherein the murphy's dropper is provided with an air filter and a liquid medicine filter which are communicated with the murphy's dropper; the air filter is communicated with the right side of the upper part of the murphy's dropper, and the opening of an air inlet pipe of the air filter is downward; the liquid medicine filter is communicated with the left side of the lower part of the murphy's dropper; each of the murphy's dropper and the liquid medicine filter is internally provided with composite filter cloth which is vertically placed; the two pieces of composite filter cloth respectively divide the murphy's dropper and the liquid medicine filter from left to right; each composite filter cloth is made by bonding woven filter cloth and a polydimethylsiloxane filter membrane, and the end part of the air inlet pipe of the air filter is provided with horizontally placed composite filter cloth. The filtering effect of the venous transfusion is improved by the high-efficiency and low-resistance impurity particle filter system, and then the potential safety hazards are completely eradicated.