The invention discloses a 2-phenoxy quinoxaline derivative and pharmaceutical use thereof. The chemical structural formula of the 2-phenoxy quinoxaline derivative is shown as formula I or II in the specification, wherein R1 and R2 are selected from hydrogen and C1-C2 alkyl; X1 is selected from fluorine, chlorine, bromine or iodine; X2 is selected from hydrogen, C1-C2 alkyl, fluorine, chlorine, bromine, iodine or nitro; X3 is selected from hydrogen, C1-C2 alkyl or nitro; and X4 is selected from hydrogen, C1-C2 alkyl, methoxy, cyano or amino. The invention also relates to a pharmaceutical composition containing the compound and application of the 2-phenoxy quinoxaline derivative in preparation of anti-influenza virus neuraminidase inhibitors.