In an in-vehicle information system including a portable information terminal and an in-vehicle device, the information terminal includes: a storage unit that stores applications; a control unit that executes a start-up application; a running application determination unit that determines an application that is executed by the control unit by a predetermined time interval; a comparison unit that compares the start-up application and the running application; and a restriction information transmission unit that transmits to the in-vehicle device restriction information corresponding to contents of action regulation imposed on the running application while a vehicle is in a traveling state based upon a result of the comparison by the comparison unit.