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Invention Publication
CN104136041A 靶向硫酸软骨素聚糖 有权

靶向硫酸软骨素聚糖
Abstract:
本发明涉及包含VAR2CSA最小结合片段的功能结合片段,涉及针对这种VAR2CSA结合片段的抗体、编码这种VAR2CSA片段的核酸，以及用于生产其的方法。本发明进一步涉及包含所述最小结合片段的VAR2CSA多肽的缀合物和融合蛋白及其用途，尤其是用于与硫酸软骨素A(CSA)的表达如硫酸软骨素A(CSA)的不适当表达相关的病症的治疗的用途。
Abstract(English):

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

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