知搜-全球专利检索

  1. 登录
  2. 注册
发明公开
CN104030942A 一种L-α-氨基丁酰胺盐酸盐的制备方法 有权 转让

一种L-α-氨基丁酰胺盐酸盐的制备方法
摘要：
本发明公开了一种全新的L-α-氨基丁酰胺盐酸盐的制备方法，包括如下步骤：(1)L-α-氨基丁酸和2,2-二甲氧基丙烷在酸性条件下反应，生成(S)-4-乙基-2,2-二甲基恶唑烷-5-酮；(2)将(S)-4-乙基-2,2-二甲基恶唑烷-5-酮氨解得到L-α-氨基丁酰胺，接着在氯化氢乙醇溶液中成盐，得到最终产物L-α-氨基丁酰胺盐酸盐。该方法操作简便，反应条件温和，易于放大。而且避免了使用剧毒性和强酸性的试剂，对环境友好。同时该方法所用的原料便宜，收率较高，并且得到的产品纯度也较高。
摘要（英）：

The invention discloses a brand-new method for preparing L-alpha-aminobutanamide hydrochloride. The method comprises the following steps: (1) enabling L-alpha-aminobutyric acid to react with 2,2-dimethoxy propane under an acidic condition, so as to generate (S)-4-ethyl-2,2-dimethyl oxazolidine-5-ketone; and (2) carrying out ammonolysis on the (S)-4-ethyl-2,2-dimethyl oxazolidine-5-ketone to obtain L-alpha-amino butanamide, and then salifying in a hydrogen ethanol solution, so as to obtain the final product, namely the L-alpha-aminobutanamide hydrochloride. The method is simple and convenient to operate, mild in reaction condition, and easy to amplify. A reagent with hypertoxicity and strong acidity is avoided, and is friendly to environment. Meanwhile, the method is cheap in used raw material and high in yield, and the obtained product is high in purity.

公开/授权文献
0/0