The invention relates to a traffic coordination control method of multiple intersections, belonging to the technical field of intelligent transportation. The method comprises the following steps: (1) establishing an intersection transportation control model containing mixed traffic flows; (2) solving the established intersection transportation control model containing the mixed traffic flows by using a chaos differential evolution algorithm. The method has the beneficial effects that the constraints of the mixed traffic flows are taken into account, and then, the traffic conditions of the intersections are more accurately reflected, so that a signal coordination scheme developed based on the traffic conditions is more reliable; minimum vehicle delay, minimum stop number and maximum pass capacity are targeted, so that the effectiveness of traffic coordination control is improved to the maximum. The traffic control method of the intersections containing the mixed traffic flows, based on the chaos differential evolution algorithm, disclosed by the invention, has the advantage that the problems of high dimensionality, nonlinearity and multiple constraints of the intersections can be excellently solved.