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发明公开
CN103946381A NGF适体及其应用 失效 - 权利终止

NGF适体及其应用
摘要：
本发明提供结合NGF并能够形成由式(I)表示的可能的二级结构的适体，其中N是选自由A,G,C,U和T组成的组的一个核苷酸,N11-N13,N21-N23,N32-N38和N42-N48是相同的或不同的且每个是键或选自由A,G,C,U和T组成的组的1或2个核苷酸,N14,N24,N31,N41,N39和N49是相同的或不同的且每个是选自由A,G,C,U和T组成的组的一个核苷酸,N14和N24,N31和N41,和N39和N49每个形成沃森-克里克(Watson-Crick)碱基对,N11-N12-N13-N14和N21-N22-N23-N24是能够组合形成茎结构的核苷酸序列,和N31-N32-N33-N34-N35-N36-N37-N38-N39和N41-N42-N43-N44-N45-N46-N47-N48-N49是能够组合形成茎结构的核苷酸序列。
摘要（英）：

The present invention relates to an aptamer binding to an NGF which may form a potential secondary structure which is expressed by formula (I). In the formula, N is one nucleotide selected from a group of A, G, C, U, and T, and N11-N13, N21-N23, N32-N38, and N42-N48 are equal to or different from one another each being one nucleotide, two nucleotides, or a combination thereof selected from the group of A, G, C, U, and T. N14, N24, N31, N41, N39, and N49 are equal to or different from one another each being one nucleotide selected from the group of A, G, C, U, and T. N14 and N24, N31 and N41, and N39 and N49 form a Watson-Crick base pair with each other as a nucleotide array capable of forming a stem structure with a combination of N11-N12-N13-N14 and N21-N22-N23-N24, and a nucleotide array capable of forming a stem structure with a combination of N31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49.

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