The invention relates to an oral preparation for preventing and treating skin aging, which is prepared from the following raw materials in parts by weight: 5-50 parts of human placenta, 3-30 parts of safflower, 5-50 parts of mulberry and 0.03-0.3 part of coenzyme Q10. The preparation method comprises the following steps: respectively taking 5-50 parts of human placenta, 3-30 parts of safflower, 5-50 parts of mulberry and 0.03-0.3 part of coenzyme Q10 in parts by weight; putting the safflower and mulberry together, decocting with water three times, merging the three decoctions, continuing decoction to concentrate into thick paste; pulverizing the human placenta in 80-100-mesh powder; and uniformly mixing the prepared thick paste and human placenta powder, drying, adding the coenzyme Q10, uniformly stirring, and making capsules. The oral preparation is based on essence and blood, has the advantages of reasonable prescription, simple compatibility and mild drug properties, has the effects of tonifying both qi and blood, regulating qi and blood, promoting growth and development and promoting metabolism, and thus, can prevent and treat skin aging, dryness, wrinkles, looseness and pigmentation.