The invention provides an optimized RFID anti-collision method. The optimized RFID anti-collision method comprises the following steps: a reader sends an activation instruction into a radio frequency field so as to activate a label, the label receives the activation instruction and sends a coded message of the label to the reader in response, and the reader decodes the coded message to judge whether a collision happens and whether the coding digit of labels to which the collision happens is larger than one; if no collision happens or the collision happens to only one digit of label, the label is directly identified; the reader sends out a command to the label to which the collision happens, the label judges whether the coded message of the label accords with the command immediately when receiving the command sent by the reader, the label does not respond if the coded message of the label does not accord with the command, a silent counter adds one to a q value, and the label can wait for a next enquiry; if the coded message of the label accords with the command, the label sends x-1 digits of encoded messages; the reader receives a feedback message sent by the label to which the collision happens and judges whether the collision happens, and the second step is repeated until all the labels are identified. The optimized RFID anti-collision method optimizes search commands and search algorithms, thereby reducing the search frequency.