The invention relates to a liquid crystal orientation agent, a liquid crystal orientation film, a manufacturing method of the liquid crystal orientation film, and a liquid crystal display element. The liquid crystal orientation agent has good printing performance with respect to a substrate and good continuous printing performance and prevents swelling of printing plates. The liquid crystal orientation agent contains at last one polymer (A) selected from the group formed by polyamide acid, polyimide, polyamide acid ester and polysiloxane, a first solvent containing more than one of N-ethyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolone, 3-methoxy-N, N-dimethylpropionamide and so on, and a second solvent containing more than one of propylene glycol diacetate, diethylene glycol diethyl ether, diisoamyl ether diacetone alcohol and so on.