The invention discloses a high-toughness high-strength steel plate and a manufacturing method thereof. The high-toughness high-strength steel plate comprises the following chemical components in percentage by mass: 0.05-0.09% of C, 0.10-0.30% of Si, 1.70-2.00% of Mn, 0.04-0.07% of Nb, 0.06-0.12% of Ti, 0.001-0.003% of rare earth RE, 0.030-0.040% of acid-soluble aluminum sol, less than or equal to 0.015% of P, less than or equal to 0.005% of S and the balance of Fe. The invention also discloses a manufacturing method of the high-toughness high-strength steel plate. The manufacturing method comprises the steps: heating a continuous-casting billet, rolling, cooling and reeling. The high-toughness high-strength steel plate disclosed by the invention has good hot cutting property, cold bending property and weldability and is suitable for load-bearing structural beam parts of large-sized engineering machinery such as containers, cranes, excavators and dumpers.